Nanofitins® can be assembled in multimers for enhanced avidity or for multi-specificity (up to 5 Nanofitins® as one multivalent compound with retained individual affinity). In every instance, neither the binding property of each single Nanofitin®, nor the function of the conjugate is affected. The creation of new products is then possible by assembling different Nanofitin® modules.

Each Nanofitin provides a unique function to the assembled molecule through its specific interaction with an element of the body. Affilogic has developed modules (i) controlling the residence time in the circulation, (ii) crossing membranes, (iii) targeting specific receptors (iv) penetrating into cells (v) generating toxicity in the cells thus invaded (vi) recruiting immune system …

It is for example possible to address multiple pathways of cancer with one poly functional molecule able to specifically reach and anchor on the tumour, recruit immune cells, reduce angiogenesis…This approach is at the core of the Nanomodule project, partially sponsored by a grant from the European Regional Development Fund (ERDF) via the Region Pays de Loire. Affilogic is partnering with the Institute of Cancer Research in Western France (Institut de Cancérologie de l’Ouest) in the pre-clinical development of a Nanofitin®-based multi-functional molecule in oncology.