Bispecific Nanofitins for tumor selective immune checkpoint inhibition
Affilogic published data on anti EGFR-PDL1 bispecific Nanofitin approach, reaching tumor selective immune checkpoint inhibition by the cross-arm binding of these two receptors, in collaboration with ICO and the CNRS UMR 6286 of Nantes University.
Full publication here
Development of multi-specific Nanofitin® molecules against lung infections
Affilogic started to develop multi-specific Nanofitin® molecules targeting global health pathogens for a treatment & vaccination approach. One particular objective is to protect individuals in lower middle income countries from infectious diseases. Such research activities are supported by a grant of $1.063M from the Bill & Melinda Gates Foundation.
Nanofitins® being 20 times smaller than antibodies, highly soluble and extremely stable proteins, they can be delivered into the lungs to address respiratory indications locally.
One scaffold, several approaches: tackling cancer diseases with Nanofitins @PEGS2022
Mathieu Cinier to present a poster showing latest data of Nanofitin used as cancer targeted therapies. Nanofitins display multiple advantages making them very attractive alternative scaffolds for cancer treatment.
Affilogic and Apellis expand R&D collaboration to develop targeted complement therapies for delivery into the brain.
Apellis Pharmaceuticals, Inc. and Affilogic today announced that the companies have expanded their research and development (R&D) collaboration, which was initially formed in 2018, to include the development of Nanofitins® targeting the transferrin receptor (TfR), which enables drugs to be transported across the blood brain barrier and into the central nervous system.
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Apellis and Affilogic published on the discovery of a novel, high-affinity Nanofitin inhibitor of C3-mediated complement activation
Apellis in collaboration with Affilogic published on the discovery of a novel, high-affinity Nanofitin inhibitor of C3-mediated complement activation, named APL-1030. Read more
Albumin binding Nanofitins, a new scaffold to extend half-life of biologics – a case study with Sanofi with their Exenatide peptide.
Affilogic published with Sanofi on using albumin binding Nanofitins as a half-life extension module with Exenatide biologically active. Read more
“Respitude” Affilogic’s project laureate of the AMI “Nouvelles Biothérapies & outils de production”.
The “Respitude project support the development of a candidate Nanofitin simultaneously targeting multiple epitopes of the SARS-Cov2 S surface protein, neutralizing its interaction with cells, and take it to phase I/IIa clinical stage.
Nanofitins being 20 times smaller than antibodies, highly soluble and extremely stable proteins, they can be easily nebulized. Affilogic already demonstrated bio-distribution of Nanofitins into different compartments of the lungs in animal models. Read More
The #FranceRelance investment plan includes 800 Million Euros (from #PIA), to help biotherapies development, stimulate competitiveness and follow the development of the French industrial environment which is necessary in order to no longer depend 95% on foreign biotherapies.
